Serena Williams has missed out on winning a record-equalling 24th Grand Slam singles title on home soil this year.
She was beaten 1-6, 6-3, 6-3 in the semi-finals of the U.S. Open by Victoria Azarenka.
The unseeded Belarusian will play Japan's Naomi Osaka in the final on Saturday.
It will be Azarenka's third final at Flushing Meadows, having lost the previous two to Williams in 2012 and 2013.
Fourth seed Osaka had earlier beaten 28th seed Jennifer Brady 7-6, 3-6, 6-3 in the other semi-final.
Rybakina beats qualifier Zheng to reach US Open semis
Second seed Elena Rybakina ended Chinese qualifier Zheng Qinwen's stirring US Open run with a 3-6 6-1 6-4 victory on Wednesday, advancing to the semi-finals and securing the world number one ranking for the first time.
Tongue routs Pakistan as England dominate third test
England are on course to complete a series whitewash after Pakistan’s brittle batting collapsed again on the opening day of the third test at Edgbaston on Wednesday.
Shelton stuns Alcaraz in late, late show to reach US Open semis
Ben Shelton beat defending champion Carlos Alcaraz 6-7(5) 6-1 6-3 1-6 7-6(10-7) in the early hours of Wednesday to reach the semi-finals of the US Open in the latest-finishing match in tournament history.
Pegula reaches third straight US Open semifinal
Jessica Pegula has reached the US Open semifinals for a third straight year, coming from a set down to beat Emma Navarro 3-6 6-4 6-3 in an all-American clash on Tuesday.
Real punish Inter errors, Haaland double lifts Man City
Real Madrid has punished two costly Inter Milan mistakes to win their Champions League opener 2-1 on Tuesday, with Kylian Mbappe and Federico Valverde scoring and goalkeeper Thibaut Courtois keeping the visitors at bay at the Santiago Bernabeu.
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