Jannik Sinner crushed Australia's Thanasi Kokkinakis 6-3 6-0 to reach the third round of Indian Wells and extend his winning streak this season to 13 matches.
The Australian Open champion will next face either 25th seed Jan-Lennard Struff or Croatian Borna Coric.
Elsewhere, Andy Murray fell to Andrey Rublev 7-6(3) 6-1. The Russian will meet Czech 32nd seed Jiri Lehecka in the third round.
Second seed Carlos Alcaraz overcame a sluggish start to dispatch Italy's Matteo Arnaldi 6-7(5) 6-0 6-1 to get his hopes of a title defence in the California desert off to a winning start.
Sixth seed Alexander Zverev and 11th seed Stefanos Tsitsipas both advanced in straight sets, while rising American Ben Shelton came from behind to score a 4-6 6-3 6-4 win over Czech Jakub Mensik in other second round action.
In the women's competition, world number one Iga Swiatek blasted past American Danielle Collins 6-3 6-0, Angelique Kerber upset 10th seed Jelena Ostapenko and defending champion Elena Rybakina withdrew with illness in second round action.
Kerber scored her biggest win in three years with an impressive 5-7 6-3 6-3 victory over hard-hitting Latvian Ostapenko.
In another upset, 22-year-old American Katie Volynets stunned sixth seed Ons Jabeur 6-4 6-4 and will face Caroline Wozniacki in the third round after the Dane outlasted Donna Vekic 7-6(5) 6-3.
Daniel Munoz has fired Colombia into the World Cup Round of 32 on Tuesday, sealing a 1-0 win over DR Congo in Group K after goalkeeper Lionel Mpasi had threatened to turn the match into a night of frustration.
Qatar's sports minister, Sheikh Hamad bin Khalifa bin Ahmed Al Thani, and national team player Assim Madibo have visited Canada midfielder Ismael Kone to check on his health after he was injured during their World Cup game, the Qatar Football Association said on Wednesday.
Ante Budimir has guided Croatia to a 1-0 win over a stubborn Panama side in their World Cup Group L clash on Tuesday, giving the Balkan side a crucial three points and eliminating the Central Americans on a night where the stakes were high for both sides.
Cristiano Ronaldo became the first player to score in six World Cups and Portugal’s all-time leading marksman at the global finals with two goals in Tuesday’s emphatic 5-0 Group K win over Uzbekistan in Houston.