According to manager Ole Gunnar Solskjaer, the France midfielder needs an operation on his ankle.
The 26-year-old only made his comeback last month, as his ankle problem kept him out since late September last year.
Scott McTominay is currently also out injured.
Pogba has played only eight times this season after having surgery to correct another ankle injury.
Brazil boss Ancelotti confident forward Neymar will recover for World Cup
Brazil's Neymar is recovering well from a calf injury and could even be available for their opening World Cup match next month, coach Carlo Ancelotti said.
PSG retain Champions League title with shoot-out win over Arsenal
Paris St Germain held their nerve in a cagey Champions League final to retain the title by beating Arsenal 4-3 on penalties as Saturday’s showdown ended 1-1 after extra time, cementing the French side's status among Europe's modern greats.
French Open champion Gauff knocked out by Potapova in third round
Defending French Open champion Coco Gauff has been knocked out of the Grand Slam following a 4-6 7-6(1) 6-4 loss to Anastasia Potapova in the third round at Roland Garros on Saturday.
Sabalenka sees off Kasatkina to reach French Open fourth round
Aryna Sabalenka has cut through the French Open chaos as the world number one beat Australia's Daria Kasatkina 6-0 7-5 on Saturday to seal her place in the fourth round after seismic upsets in the previous two days at Roland Garros.
Parry stuns Anisimova to reach first Grand Slam fourth round at French Open
Diane Parry, the last Frenchwoman standing in the French Open women's draw, has pulled off a stunning 6-3 4-6 7-6(3) victory over American Amanda Anisimova on Saturday, advancing to the fourth round of a Grand Slam for the first time in her career.
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