According to manager Ole Gunnar Solskjaer, the France midfielder needs an operation on his ankle.
The 26-year-old only made his comeback last month, as his ankle problem kept him out since late September last year.
Scott McTominay is currently also out injured.
Pogba has played only eight times this season after having surgery to correct another ankle injury.
England dismiss Pakistan for 110 to seize control of Lord's test
A day Pakistan began with high hopes of making a real contest of the second test ended with them plummeting towards another heavy defeat as England seized total control at Lord's, bowling them out for 110 and building a lead of 261 on Friday.
Raphinha, Fermin score as Barcelona beat Athletic in home opener
Raphinha and Fermin Lopez scored as Barcelona beat Athletic Bilbao 2-0 at the Camp Nou on Thursday in their first home match of the LaLiga season.
Celtic and Rangers to play cup match behind closed doors after pitch invasion
'Old Firm' rivals Celtic and Rangers must play their next home Scottish Cup matches behind closed doors after clashes between the Glasgow clubs' fans following this year's quarter-final at Ibrox.
Chelsea and Fulham reach League Cup third round as Welbeck scores on debut
Chelsea has eased into the League Cup third round with a 2-0 victory over third-tier Luton Town on Thursday as Danny Welbeck marked his debut with a goal in Xabi Alonso's first competitive home match in charge.
PSG to meet Barca, Man City as Champions League draw throws up marquee ties
Champions League holders Paris St Germain will take on Barcelona and Manchester City in this season's league phase, while record 15-time champions Real Madrid will face Inter Milan and Arsenal after Thursday's draw in Monaco set up several mouth-watering clashes.
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Officially the UAE's favourite DJ, Dany Neville makes sure you have the soundtrack you need every Saturday night.
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