According to manager Ole Gunnar Solskjaer, the France midfielder needs an operation on his ankle.
The 26-year-old only made his comeback last month, as his ankle problem kept him out since late September last year.
Scott McTominay is currently also out injured.
Pogba has played only eight times this season after having surgery to correct another ankle injury.
Green still off-colour for winless Kolkata
Kolkata Knight Riders are confident that marquee signing Cameron Green will eventually come good but the Indian Premier League's only winless team need the Australia all-rounder to show why they made him the league's most expensive overseas recruit.
Dembele double at Liverpool fires PSG into Champions League semis
Ousmane Dembele struck twice to confirm Paris St Germain's place in the Champions League semi-finals with a 2-0 victory over Liverpool on Tuesday, sealing a 4-0 aggregate win in their quarter-final tie at a rain-soaked Anfield.
Ex-England international Shelvey named Arabian Falcons FC manager
Former England midfielder Jonjo Shelvey has retired from playing and will take over as manager of third-tier United Arab Emirates side Arabian Falcons FC.
Muzarabani given two-year PSL ban after IPL switch
Blessing Muzarabani has been banned from the Pakistan Super League (PSL) for two years after the Zimbabwe fast bowler joined Indian Premier League (IPL) side Kolkata Knight Riders, despite having agreed to play for PSL team Islamabad United.
Draper vows to overcome injury woes after Barcelona exit
Jack Draper vowed to work his way out of his injury woes after being forced to retire with a right leg problem midway through his first-round match against Tomas Etcheverry at the Barcelona Open on Monday.
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