England beat Ireland and France by 12 and 36 points respectively in their first two matches of the campaign.
They are currently ranked third in the world.
Play from the Millennium Stadium in Cardiff gets underway at 8:45 PM UAE time.
Meanwhile Scotland travel to France for their latest Six Nations fixture.
Action from the Stade de France starts at 6:15 PM UAE time.
Sabalenka defeats Ann Li at rain-hit Miami Open
World number one and newly crowned Indian Wells champion Aryna Sabalenka has survived a stern battle against her American opponent, grinding out a 7-6(5) 6-4 victory to reach the third round.
Draper, Ruud knocked out at rain-hit Miami Open
Britain's Jack Draper has suffered a surprise defeat to American Reilly Opelka in the second round of the Miami Open on Friday, while Ethan Quinn claimed the biggest win of his career by upsetting 11th seed Casper Ruud.
Alisson ruled out of Brazil squad due to injury
Alisson will miss Brazil’s international friendlies against France and Croatia next week after the goalkeeper was ruled out with an injury, the Brazilian Football Federation said on Friday.
Maguire sees red as Man Utd held to draw at Bournemouth
Manchester United defender Harry Maguire was shown a red card for conceding the penalty that led to Bournemouth grabbing a 2-2 Premier League draw at the Vitality Stadium on Friday, the home side twice coming from behind to secure a point.
Injured Salah out of Liverpool's Brighton trip, says Slot
Injured Liverpool forward Mohamed Salah will miss Saturday's trip to Brighton & Hove Albion in the Premier League and Egypt's friendly with Spain on March 31, manager Arne Slot said on Friday.
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Jacob sits down with LANY for a fun, honest catch up that fans will love. 🎤
Watch the all new episode of I'm Not Your Dad. 🎙️
Get the latest UAE and world news from our award winning team of journalists.
The legendary Craig David joins The Kris Fade Show for an unforgettable chat!
