Roger Federer took one step closer to a fourth Miami Open crown after defeating Canadian teenager Denis Shapovalov.
"It was a tactical match by me... I'm happy I was able to play with variations," said the 37-year-old Swiss, who won 6-2 6-4.
"I enjoyed it. I think I played very well. I had to. Because I think when you let Denis play, he's got some serious power, and he gets rhythm going. He can really put you in uncomfortable situations."
Defending champion Isner also bested a Canadian teenager, 18-year-old qualifier Felix Auger-Aliassime, 7-6 (3), 7-6 (4).

All-Star Sumo Competition to take place in Abu Dhabi for first time
Top seed Zverev avoids upset in five-set thriller
Swiatek banks on renewed confidence as Medvedev battles to regain lost form
Birthday boy Monfils beats Vallejo in first round of his last US Open
Home favourite Gauff storms past Sonmez at US Open