Jason Roy and captain Joe Root both smashed centuries as the tourists easily reached their target of 361 with eight balls to spare in Barbados.
It was their highest ever run-chase in the format.
Chris Gayle's innings of 139 off 129 balls went in vain as the Windies' poor form in ODI cricket continued.
The second encounter of the five-match series will be played on Friday.
Inter secure Serie A title in heated win over Milan
Inter Milan won their 20th Serie A title on Monday after a 2-1 win at AC Milan gave Simone Inzaghi's side an unassailable lead in the standings.
Bellingham's strike hands Real comeback win over Barcelona
LaLiga leaders Real Madrid's pursuit of a record-extending 36th Spanish title gathered momentum after Jude Bellingham scored a goal in added time to secure a 3-2 comeback win over Barcelona on Sunday.
Kohli unhappy with umpire after new full toss review method rules him out
Virat Kohli was left fuming when a new method applied to the ball tracking technology ruled him out on a full toss delivery that he thought went above his waist in Sunday's loss at Kolkata Knight Riders.
Man Utd overcome Coventry in FA Cup semi-final classic
Manchester United survived one of the most astonishing FA Cup semi-final comebacks ever to beat second-tier Coventry City on penalties after a spellbinding clash ended 3-3 after extra time at Wembley Stadium on Sunday.
Rybakina strolls to Stuttgart title
Elena Rybakina had little trouble in seeing off Marta Kostyuk 6-2 6-2 to win the Stuttgart Open on Sunday, her third title this year.
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Brent Black has the biggest stories of the day and the stuff you might have missed.
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BRED Abu Dhabi, Presented by Hypebeast, is back April 24-28 in Yas Bay. The line up is next level and locked in.
The boys tried their 'pick up' lines on Mais Vault and things did not go according to plan...
Hear Maz & James chatting to the featured artists every month with Flash Entertainment.
One of the most talked about comedians in the world takes over The Kris Fade Show. Watch the full interview here...
