Jason Roy and captain Joe Root both smashed centuries as the tourists easily reached their target of 361 with eight balls to spare in Barbados.
It was their highest ever run-chase in the format.
Chris Gayle's innings of 139 off 129 balls went in vain as the Windies' poor form in ODI cricket continued.
The second encounter of the five-match series will be played on Friday.
Eala stuns Swiatek at Wimbledon, Mertens ousts Rybakina
Defending champion Iga Swiatek was knocked out of the third round of Wimbledon after a 7-6(9) 6-2 loss to rising Filipina Alexandra Eala at the All England Club on Saturday.
India's 15-year-old batting sensation Sooryavanshi makes senior debut
India batting prodigy Vaibhav Sooryavanshi became the youngest player to represent the country after receiving his maiden international cap ahead of Saturday's Twenty20 International against England in Manchester, surpassing Sachin Tendulkar's long-standing record.
Antonelli denies Hamilton a home sprint win
Kimi Antonelli beat home favourite Lewis Hamilton to win the British Grand Prix sprint race for Mercedes on Saturday and forge 43 points clear in the Formula One standings.
Colombia beat Ghana 1-0 to set up Switzerland showdown
Jhon Arias scored the only goal as Colombia beat Ghana 1-0 in sweltering conditions in Kansas City on Friday to reach the World Cup last 16, continuing a quietly impressive campaign that has established them as dangerous outsiders.
Egypt sink Australia on penalties to secure first World Cup knockout win
Egypt held their nerve to beat Australia 4-2 on penalties and secure their first World Cup knockout victory following a 1-1 draw after extra time in a cagey last-32 match at Dallas Stadium.
7:00pm - 11:00pm
Officially the UAE's favourite DJ, Dany Neville makes sure you have the soundtrack you need every Saturday night.
11:00pm - Midnight
National Treasure <New>
Drake
Eenie Meenie
Sean Kingston and Justin Bieber
Movin' To The Sun <New>
Hugel & Imael Angel & Ultra Nate