Jason Roy and captain Joe Root both smashed centuries as the tourists easily reached their target of 361 with eight balls to spare in Barbados.
It was their highest ever run-chase in the format.
Chris Gayle's innings of 139 off 129 balls went in vain as the Windies' poor form in ODI cricket continued.
The second encounter of the five-match series will be played on Friday.
Ruthless Man City thump Newcastle to reach League Cup final
Omar Marmoush scored twice as Manchester City set up a League Cup final date with Arsenal after a comprehensive 3-1 second-leg victory over visiting Newcastle United secured a 5-1 aggregate win in their semi-final on Wednesday.
Ethara named F1 promoter of the year
Ethara, the promoter of the Formula 1 Etihad Airways Abu Dhabi Grand Prix, has been named Promoter of the Year at the annual F1 Promoter Awards in London.
Alexandra Eala stages comeback to reach Mubadala quarter-finals
Filipina teenager Alexandra Eala fought back from the brink of defeat to reach the quarter-finals of the Mubadala Abu Dhabi Open after a marathon win over Aliaksandra Sasnovich.
F1 legend Mika Häkkinen turns brand ambassador for Only Legends Drive UAE
Two-time Formula One World Champion Mika Häkkinen will step in as the brand ambassador of the ultra-luxury four-day supercar rally - Only Legends Drive UAE, that kicks off on March 19.
Guardiola vows to speak up for victims of global conflicts
Pep Guardiola said he will continue to use his platform as Manchester City manager to speak up for victims of global conflicts and violence.
6:00am - 10:00am
Kris, Priti and Rossi host the UAE's biggest radio show. It's full of fun, laughs and it's Where The Stars Live.
The legendary Craig David joins The Kris Fade Show for an unforgettable chat!
Hear Maz & James chatting to the featured artists every month with Flash Entertainment.
S.N.E joins The Fusion with Eddie for an unforgettable episode! 🔥
The super-star and multi-award-winning singer-songwriter, Jason Derulo is bringing the heat to Dubai.
