England bowled West Indies out for 45 - the second lowest total in international Twenty20 history - to win by 137 runs in St Kitts.
Joe Root's 55 runs and Sam Billings' brilliant knock of 87 off 47 balls helped to win with ease, taking an unassailable 2-0 lead in the series.
This is England's biggest margin of victory by runs in T20s and the fourth biggest of all time.
The final T20 will be played in St Kitts at 20:00 GMT on Sunday.

Budimir gives Croatia win to eliminate Panama in Group L
England fail to break down Ghana in goalless draw
Ronaldo guides Portugal to big win over Uzbekistan
US eases restrictions on Iran's world cup team
Pant returns to Delhi in IPL swap with Kuldeep