Arsenal and Chelsea made it through to the Europa League last-eight while Inter and Sevilla were knocked out.
Arsenal are into the quarter-finals of the Europa League after beating Rennes 3-0 at the Emirates Stadium.
Pierre-Emerick Aubameyang scored twice and set-up Ainsley Maitland-Niles as the Gunners overturned a two-goal deficit from the first leg, progressing 4-3 overall.
They're joined in the last-eight by London rivals Chelsea, who thrashed Dynamo Kiev 5-0 away from home to complete an 8-0 aggregate victory.
Olivier Giroud claimed a hat-trick, with Marcus Alonso and Callum Hudson-Odoi also getting on the scoresheet.
Italian giants Internazionale were knocked out by Eintracht Frankfurt as Luka Jovic got the only goal of the tie for the German outfit at the San Siro.
That wasn't the only shock result however, as Spanish side Sevilla, who have won the competition a record five times, lost 4-3 to Slavia Prague after extra-time to go out 6-5 on aggregate.
Elsewhere, Villarreal beat Zenit St Petersburg 2-1 to complete a 5-2 aggregate win, Benfica overturned a 1-0 deficit from the first leg to beat Dinamo Zagreb 3-1 overall and Valencia secured a 1-1 draw at Krasnador to progress 3-2.
Paris St Germain picked up where they left off following last season’s Champions League triumph as they kicked off their new campaign with an impressive 4-0 win over Atalanta at the Parc des Princes on Wednesday.
Liverpool captain Virgil van Dijk headed home a last-gasp goal in stoppage time to lead Arne Slot's men to a thrilling 3-2 victory over Atletico Madrid in the opening game of their Champions League campaign on Wednesday at Anfield.
Pakistan delayed their match against the UAE by an hour on Wednesday after considering a withdrawal from the Asia Cup in protest at a match referee whom they say condoned unsportsmanlike behaviour by India at the weekend.
Portuguese club Benfica are set to name Jose Mourinho as its head coach following the sacking of Bruno Lage in the aftermath of their 3-2 Champions League defeat by Qarabag, Portuguese TV station RTP reported on Wednesday.
Celebrating a history-making year in completing the career Grand Slam at Augusta National, Rory McIlroy has confirmed his return to Emirates Golf Club to headline the 2026 Hero Dubai Desert Classic, taking place from January 22–25, 2026.