The US military said it destroyed a drone fired by the Yemeni Houthis on Saturday, with another presumed to have crashed into the Red Sea.
There were no reports of damage or injuries from ships in the vicinity, the US Central Command (CENTCOM) said in a statement.
CETNCOM also said it destroyed five unmanned surface vessels and one UAV in self-defence, in Houthi-controlled areas of Yemen.
"It was determined these weapons presented an imminent threat to merchant vessels and US Navy ships in the region," the statement read.
Months of Houthi attacks in the Red Sea have disrupted global shipping, forcing firms to re-route to longer and more expensive journeys around Southern Africa, and stoked fears that the Israel-Hamas war could spread to destabilise the wider Middle East.
The US and Britain have carried out strikes against Houthi targets in response to the attacks on shipping.
Judges at the top United Nations court ordered Israel on Friday to halt its military assault on the southern Gaza city of Rafah, in a landmark emergency ruling on South Africa's case accusing Israel of genocide.
Twenty people who were aboard a Singapore Airlines flight that hit severe turbulence and diverted to Bangkok for an emergency landing on Tuesday remain in intensive care. Others are being treated for spinal cord and brain injuries.
A two-storey restaurant building collapsed on the beach in Palma de Mallorca killing at least four people and injuring 16 people in the tourism hot spot in Spain's Balearic Islands.
Israeli forces killed 35 Palestinians in aerial and ground bombardments across the Gaza Strip on Thursday and battled in close combat with Hamas in areas of the southern city of Rafah, health officials and Hamas media said.