Syria's President Bashar al-Assad and his wife Asma have tested positive for COVID-19 after showing minor symptoms, his office said on Monday.
The pair are in good health and would keep working in isolation at home, the statement said.
Syria has seen a sharp rise in infections since mid-February. Health and aid officials say it remains difficult to gauge the full size of the outbreak given the lack of testing facilities in a fragile health system devastated by a decade of war.
Assad joins a growing list of world leaders who have tested positive for COVID-19, alongside Britain's Boris Johnson, France's Emmanuel Macron and former U.S. President Donald Trump.
Health workers said the authorities underplayed the size of the outbreak for most of last year, when official figures remained low as hospitals were overwhelmed and death notices appeared in newspapers.
The government denied undercounting the figures and has acknowledged in the last two months the country could be on the verge of a major spike.
It has urged people to wear face masks, take sanitary measures and avoid crowded areas.
A Palestinian teen has been shot dead during an Israeli military raid in the occupied West Bank on Wednesday, the official Palestinian news agency Wafa reported.
Some 287 candidates will be considered for the 2026 Nobel Peace Prize, the secretary of the Norwegian Nobel Committee said on Thursday, with US President Donald Trump likely to be among the nominees.
At least 17 migrants have died, and nine are missing after their boat broke down and drifted for eight days in the Mediterranean Sea, Libya's Red Crescent and Libyan security sources said on Wednesday.
Israel has begun taking control of aid ships bound for Gaza far from Israeli shores, Israeli army radio cited an Israeli source as saying on Wednesday.
Donald Trump discussed how to mitigate the impact of a possible months-long US blockade of Iran's ports with US oil companies, a White House official said on Wednesday, as the US president urged Tehran to 'get smart soon' and sign a deal.