Bahrain will suspend dine-in services at restaurants and cafes and move public and private schools to remote learning for three weeks to contain the spread of the coronavirus, the health ministry said.
It said it had detected a new variant of coronavirus in a number of cases, without specifying which kind.
The new lockdown measures will come into effect on Sunday.
There has been an uptick in coronavirus cases in the Gulf kingdom since December. The country registered 459 new cases on Wednesday, adding to a total of nearly 100,000 since the start of the pandemic, with 370 deaths.
The small island state has the third highest rate of vaccinations per capita in the world so far, according to the Our World in Data website, which is run by an Oxford University research programme.
Bahrain offers its citizens either the Pfizer/BioNTech vaccine or one manufactured by Chinese state-backed pharmaceutical giant Sinopharm free of charge.
The kingdom also approved the AstraZeneca COVID-19 vaccine on Monday for emergency use.
A Palestinian teen has been shot dead during an Israeli military raid in the occupied West Bank on Wednesday, the official Palestinian news agency Wafa reported.
At least 17 migrants have died, and nine are missing after their boat broke down and drifted for eight days in the Mediterranean Sea, Libya's Red Crescent and Libyan security sources said on Wednesday.
Israel has begun taking control of aid ships bound for Gaza far from Israeli shores, Israeli army radio cited an Israeli source as saying on Wednesday.
Donald Trump discussed how to mitigate the impact of a possible months-long US blockade of Iran's ports with US oil companies, a White House official said on Wednesday, as the US president urged Tehran to 'get smart soon' and sign a deal.
Seven people have died after a 2.5 metre wall at a hospital complex collapsed in the southern Indian city of Bengaluru, a state official said on Wednesday.