At least 12 people were killed and nine injured on Tuesday evening when gunmen opened fire at an informal settlement in Cleveland, east of Johannesburg, police said on Wednesday.
Police said in a statement that they had launched a manhunt for more than 10 suspects following the attack at the Jumpers informal settlement.
The motive for the attack is not known.
Police said the suspects arrived in a white Toyota Quantum, entered the settlement from two access points and opened fire at multiple locations before fleeing in the same vehicle.
South Africa has one of the world's highest murder rates, averaging about 60 a day.
US, German scientists win Nobel medicine prize for work on light and brain
Spanish PM Sanchez calls snap election for November 29
Hundreds of French schools stay closed ahead of nationwide day of student protests
Thousands of Imran Khan supporters start march to Pakistani capital, party says
US removes bombers from UK base at centre of suspected Iranian plot
