The famous franchise will keep its leading man Harrison Ford, but lose its renowned director, when filming begins this summer.
Steven Spielberg says he won't be directing Indiana Jones 5 in order to give a younger director with a new perspective a chance.
He will however, stay on as "a hands-on" producer.
The famed filmmaker directed the first four movies in the franchise, starting with Raiders Of The Lost Ark 39 years ago.
It will be Ford's fifth time playing the lovable archaeologist following Raiders Of The Lost Ark (1981), Temple Of Doom (1984), The Last Crusade (1989) and Kingdom Of The Crystal Skull (2008).


Reality TV star Kim Kardashian reveals brain aneurysm diagnosis
Global Village celebrates 30 years with dazzling new parade
Oscar-winning 'Dune' studio to hold Abu Dhabi masterclass in November
Emma Stone brags about not breaking bones for film 'Bugonia'
Natural History Museum Abu Dhabi gears up for November opening
Train to light up Dubai's Coca-Cola Arena in February