Bahrain will suspend dine-in services at restaurants and cafes and move public and private schools to remote learning for three weeks to contain the spread of the coronavirus, the health ministry said.
It said it had detected a new variant of coronavirus in a number of cases, without specifying which kind.
The new lockdown measures will come into effect on Sunday.
There has been an uptick in coronavirus cases in the Gulf kingdom since December. The country registered 459 new cases on Wednesday, adding to a total of nearly 100,000 since the start of the pandemic, with 370 deaths.
The small island state has the third highest rate of vaccinations per capita in the world so far, according to the Our World in Data website, which is run by an Oxford University research programme.
Bahrain offers its citizens either the Pfizer/BioNTech vaccine or one manufactured by Chinese state-backed pharmaceutical giant Sinopharm free of charge.
The kingdom also approved the AstraZeneca COVID-19 vaccine on Monday for emergency use.
The Israeli military maintained its pressure on Gaza City with heavy bombardments overnight, residents said, ahead of a Thursday meeting between Prime Minister Benjamin Netanyahu and his ministers on plans to seize the enclave's largest city.
Russian President Vladimir Putin is prepared to meet Volodymyr Zelenskyy but all issues must be worked through first and there's a question about the Ukrainian leader's authority to sign a peace deal, Foreign Minister Sergei Lavrov said on Thursday.
United Nations Secretary-General Antonio Guterres on Thursday called for an immediate ceasefire in Gaza, after Israel announced the first steps of an operation to take over Gaza City.
Ukrainian President Volodymyr Zelenskyy said Kyiv would like a "strong reaction" from Washington if Russian President Vladimir Putin was not willing to sit down for a bilateral meeting with him.
Russian overnight attack killed one person, injured at least 18, and struck a US electronics manufacturer in western Ukraine, Ukrainian officials said on Thursday.